Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models

Environmental or occupational exposure of humans to trichloroethylene (TCE) has been associated with different extrahepatic toxic effects, including nephrotoxicity and neurotoxicity. Bioactivation of TCE via the glutathione (GSH) conjugation pathway has been proposed as underlying mechanism, althoug...

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Detalles Bibliográficos
Autores principales: Capinha, Liliana, Zhang, Yaran, Holzer, Anna-Katharina, Ückert, Anna-Katharina, Zana, Melinda, Carta, Giada, Murphy, Cormac, Baldovini, Jenna, Mazidi, Zahra, Grillari, Johannes, Dinnyes, Andras, van de Water, Bob, Leist, Marcel, Commandeur, Jan N. M., Jennings, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
In Vitro Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859926/
https://www.ncbi.nlm.nih.gov/pubmed/36576512
http://dx.doi.org/10.1007/s00204-022-03436-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859926/
https://www.ncbi.nlm.nih.gov/pubmed/36576512
http://dx.doi.org/10.1007/s00204-022-03436-6

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