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A single cell-based computational platform to identify chemical compounds targeting desired sets of transcription factors for cellular conversion
Cellular conversion can be induced by perturbing a handful of key transcription factors (TFs). Replacement of direct manipulation of key TFs with chemical compounds offers a less laborious and safer strategy to drive cellular conversion for regenerative medicine. Nevertheless, identifying optimal ch...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9859931/ https://www.ncbi.nlm.nih.gov/pubmed/36400030 http://dx.doi.org/10.1016/j.stemcr.2022.10.013 |