Stress-induced reversible cell-cycle arrest requires PRC2/PRC1-mediated control of mitophagy in Drosophila germline stem cells and human iPSCs

Following acute genotoxic stress, both normal and tumorous stem cells can undergo cell-cycle arrest to avoid apoptosis and later re-enter the cell cycle to regenerate daughter cells. However, the mechanism of protective, reversible proliferative arrest, “quiescence,” remains unresolved. Here, we sho...

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Detalles Bibliográficos
Autores principales: Taslim, Tommy H., Hussein, Abdiasis M., Keshri, Riya, Ishibashi, Julien R., Chan, Tung C., Nguyen, Bich N., Liu, Shuozhi, Brewer, Daniel, Harper, Stuart, Lyons, Scott, Garver, Ben, Dang, Jimmy, Balachandar, Nanditaa, Jhajharia, Samriddhi, Castillo, Debra del, Mathieu, Julie, Ruohola-Baker, Hannele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860083/
https://www.ncbi.nlm.nih.gov/pubmed/36493777
http://dx.doi.org/10.1016/j.stemcr.2022.11.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860083/
https://www.ncbi.nlm.nih.gov/pubmed/36493777
http://dx.doi.org/10.1016/j.stemcr.2022.11.004

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