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Tandem mass tag-based thermal proteome profiling for the discovery of drug-protein interactions in cancer cells
Identification of effector targets is imperative to the characterization of the mechanisms of action of novel small molecules. Here, we describe steps to identify effector drug-protein interactions in lysates derived from cancer cell lines using a thermal proteome profiling (TPP) protocol. Building...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860163/ https://www.ncbi.nlm.nih.gov/pubmed/36856765 http://dx.doi.org/10.1016/j.xpro.2022.102012 |