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Identification of transient intermediates during spliceosome activation by single molecule fluorescence microscopy

Spliceosome activation is the process of creating the catalytic site for RNA splicing and occurs de novo on each intron following spliceosome assembly. Dozens of factors bind to or are released from the activating spliceosome including the Lsm2-8 heteroheptameric ring that binds the U6 small nuclear...

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Detalles Bibliográficos
Autores principales: Fu, Xingyang, Kaur, Harpreet, Rodgers, Margaret L., Montemayor, Eric J., Butcher, Samuel E., Hoskins, Aaron A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860250/
https://www.ncbi.nlm.nih.gov/pubmed/36417433
http://dx.doi.org/10.1073/pnas.2206815119