Discovery of small molecules that target a tertiary-structured RNA

There is growing interest in therapeutic intervention that targets disease-relevant RNAs using small molecules. While there have been some successes in RNA-targeted small-molecule discovery, a deeper understanding of structure–activity relationships in pursuing these targets has remained elusive. On...

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Detalles Bibliográficos
Autores principales: Menichelli, Elena, Lam, Bianca J., Wang, Yu, Wang, Vivian S., Shaffer, Jennifer, Tjhung, Katrina F., Bursulaya, Badry, Nguyen, Truc Ngoc, Vo, Todd, Alper, Phillip B, McAllister, Christopher S, Jones, David H., Spraggon, Glen, Michellys, Pierre-Yves, Joslin, John, Joyce, Gerald F., Rogers, Jeff
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860313/
https://www.ncbi.nlm.nih.gov/pubmed/36413497
http://dx.doi.org/10.1073/pnas.2213117119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860313/
https://www.ncbi.nlm.nih.gov/pubmed/36413497
http://dx.doi.org/10.1073/pnas.2213117119

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