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Titin force in muscle cells alters lattice order, thick and thin filament protein formation

Skeletal muscle force production is increased at longer compared to shorter muscle lengths because of length-dependent priming of thick filament proteins in the contractile unit before contraction. Using small-angle X-ray diffraction in combination with a mouse model that specifically cleaves the st...

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Detalles Bibliográficos
Autores principales: Hessel, Anthony L., Ma, Weikang, Mazara, Nicole, Rice, Paige E., Nissen, Devin, Gong, Henry, Kuehn, Michel, Irving, Thomas, Linke, Wolfgang A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860331/
https://www.ncbi.nlm.nih.gov/pubmed/36409887
http://dx.doi.org/10.1073/pnas.2209441119