Attenuating iPSC reprogramming stress with dominant-negative BET peptides

Generation of induced pluripotent stem cells (iPSCs) is inefficient and stochastic. The underlying causes for these deficiencies are elusive. Here, we showed that the reprogramming factors (OCT4, SOX2, and KLF4, collectively OSK) elicit dramatic reprogramming stress even without the pro-oncogene MYC...

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Detalles Bibliográficos
Autores principales: Hossain, Md Emon, Cevallos, Ricardo Raul, Zhang, Ruowen, Hu, Kejin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860338/
https://www.ncbi.nlm.nih.gov/pubmed/36691621
http://dx.doi.org/10.1016/j.isci.2022.105889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860338/
https://www.ncbi.nlm.nih.gov/pubmed/36691621
http://dx.doi.org/10.1016/j.isci.2022.105889

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