The N-terminal domain of human mitochondrial helicase Twinkle has DNA-binding activity crucial for supporting processive DNA synthesis by polymerase γ

Twinkle is the ring-shaped replicative helicase within the human mitochondria with high homology to bacteriophage T7 gp4 helicase–primase. Unlike many orthologs of Twinkle, the N-terminal domain (NTD) of human Twinkle has lost its primase activity through evolutionarily acquired mutations. The NTD h...

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Detalles Bibliográficos
Autores principales: Johnson, Laura C., Singh, Anupam, Patel, Smita S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860392/
https://www.ncbi.nlm.nih.gov/pubmed/36528058
http://dx.doi.org/10.1016/j.jbc.2022.102797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860392/
https://www.ncbi.nlm.nih.gov/pubmed/36528058
http://dx.doi.org/10.1016/j.jbc.2022.102797

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