Cargando…

The N-terminal domain of human mitochondrial helicase Twinkle has DNA-binding activity crucial for supporting processive DNA synthesis by polymerase γ

Twinkle is the ring-shaped replicative helicase within the human mitochondria with high homology to bacteriophage T7 gp4 helicase–primase. Unlike many orthologs of Twinkle, the N-terminal domain (NTD) of human Twinkle has lost its primase activity through evolutionarily acquired mutations. The NTD h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Johnson, Laura C., Singh, Anupam, Patel, Smita S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860392/ https://www.ncbi.nlm.nih.gov/pubmed/36528058 http://dx.doi.org/10.1016/j.jbc.2022.102797

Ejemplares similares

Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE
por: Sen, Doyel, et al.
Publicado: (2016)

The N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities
por: Farge, Géraldine, et al.
Publicado: (2008)

TWINKLE and Other Human Mitochondrial DNA Helicases: Structure, Function and Disease
por: Peter, Bradley, et al.
Publicado: (2020)

Structural and dynamic basis of DNA capture and translocation by mitochondrial Twinkle helicase
por: Li, Zhuo, et al.
Publicado: (2022)

The hexameric structure of the human mitochondrial replicative helicase Twinkle
por: Fernández-Millán, Pablo, et al.
Publicado: (2015)

The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis
por: Jemt, Elisabeth, et al.
Publicado: (2011)

Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes
por: Wanrooij, Sjoerd, et al.
Publicado: (2007)

The Dictyostelium discoideum homologue of Twinkle, Twm1, is a mitochondrial DNA helicase, an active primase and promotes mitochondrial DNA replication
por: Harman, Ashley, et al.
Publicado: (2018)

Structural insight and characterization of human Twinkle helicase in mitochondrial disease
por: Riccio, Amanda A., et al.
Publicado: (2022)

TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication
por: Milenkovic, Dusanka, et al.
Publicado: (2013)

Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element
por: Jemt, Elisabeth, et al.
Publicado: (2015)

Structural basis for adPEO-causing mutations in the mitochondrial TWINKLE helicase
por: Peter, Bradley, et al.
Publicado: (2019)

Corrigendum to: Structural basis for adPEO-causing mutations in the mitochondrial TWINKLE helicase
por: Peter, Bradley, et al.
Publicado: (2020)

Implications of Membrane Binding by the Fe-S Cluster-Containing N-Terminal Domain in the Drosophila Mitochondrial Replicative DNA Helicase
por: So, Minyoung, et al.
Publicado: (2021)

DNA Helicase–Polymerase Coupling in Bacteriophage DNA Replication
por: Lo, Chen-Yu, et al.
Publicado: (2021)

Ortholog of the polymerase theta helicase domain modulates DNA replication in Trypanosoma cruzi
por: de Lima, Loyze P., et al.
Publicado: (2019)

Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB
por: Hensen, Fenna, et al.
Publicado: (2019)

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling
por: Goffart, Steffi, et al.
Publicado: (2009)

The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability
por: Yankiwski, Victor, et al.
Publicado: (2001)

Twinkling sign?
por: Tuma, Jan
Publicado: (2010)

Three-Dimensional Structure of N-Terminal Domain of DnaB Helicase and Helicase-Primase Interactions in Helicobacter pylori
por: Kashav, Tara, et al.
Publicado: (2009)

DNA Polymerase-Parental DNA Interaction Is Essential for Helicase-Polymerase Coupling during Bacteriophage T7 DNA Replication
por: Lo, Chen-Yu, et al.
Publicado: (2022)

Mutations in mitochondrial DNA polymerase γ promote breast tumorigenesis
por: Singh, Keshav K., et al.
Publicado: (2009)

Characterization of Staphylococcus aureus Primosomal DnaD Protein: Highly Conserved C-Terminal Region Is Crucial for ssDNA and PriA Helicase Binding but Not for DnaA Protein-Binding and Self-Tetramerization
por: Huang, Yen-Hua, et al.
Publicado: (2016)

The domain structure of Helicobacter pylori DnaB helicase: the N-terminal domain can be dispensable for helicase activity whereas the extreme C-terminal region is essential for its function
por: Nitharwal, Ram Gopal, et al.
Publicado: (2007)

Not all that twinkles is gold
por: Levine, Rykiel, et al.
Publicado: (2023)

Borrowing Nuclear DNA Helicases to Protect Mitochondrial DNA
por: Ding, Lin, et al.
Publicado: (2015)

Structural and biochemical characterization of an RNA/DNA binding motif in the N-terminal domain of RecQ4 helicases
por: Marino, Francesca, et al.
Publicado: (2016)

The Overexpression of Twinkle Helicase Ameliorates the Progression of Cardiac Fibrosis and Heart Failure in Pressure Overload Model in Mice
por: Tanaka, Atsushi, et al.
Publicado: (2013)

The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication
por: Macao, Bertil, et al.
Publicado: (2015)

Arabidopsis thaliana organelles mimic the T7 phage DNA replisome with specific interactions between Twinkle protein and DNA polymerases Pol1A and Pol1B
por: Morley, Stewart A., et al.
Publicado: (2019)

Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress
por: Ikeda, Masataka, et al.
Publicado: (2015)

The helicase-binding domain of Escherichia coli DnaG primase interacts with the highly conserved C-terminal region of single-stranded DNA-binding protein
por: Naue, Natalie, et al.
Publicado: (2013)

The accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells
por: Di Re, M., et al.
Publicado: (2009)

The human papillomavirus DNA helicase E1 binds, stimulates, and confers processivity to cellular DNA polymerase epsilon
por: Chojnacki, Michaelle, et al.
Publicado: (2018)

UvrD helicase–RNA polymerase interactions are governed by UvrD’s carboxy-terminal Tudor domain
por: Kawale, Ashish A., et al.
Publicado: (2020)

Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities
por: Sebesta, Marek, et al.
Publicado: (2011)

The accessory subunit B of DNA polymerase γ is required for mitochondrial replisome function
por: Farge, Géraldine, et al.
Publicado: (2007)

The ubiquitin-binding domain of DNA polymerase η directly binds to DNA clamp PCNA and regulates translesion DNA synthesis
por: Manohar, Kodavati, et al.
Publicado: (2021)

Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends
por: Schaub, Jeffrey M, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_eh34j9nt0ppmcrfiea2fq359fp