Oncogenic RAS promotes MYC protein stability by upregulating the expression of the inhibitor of apoptosis protein family member Survivin

The small GTPase KRAS is frequently mutated in pancreatic cancer and its cooperation with the transcription factor MYC is essential for malignant transformation. The key to oncogenic KRAS and MYC working together is the stabilization of MYC expression due to KRAS activating the extracellular signal–...

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Detalles Bibliográficos
Autores principales: Chang, Wen-Hsuan, Liu, Yinzhe, Hammes, Emma A., Bryant, Kirsten L., Cerione, Richard A., Antonyak, Marc A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860443/
https://www.ncbi.nlm.nih.gov/pubmed/36581205
http://dx.doi.org/10.1016/j.jbc.2022.102842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860443/
https://www.ncbi.nlm.nih.gov/pubmed/36581205
http://dx.doi.org/10.1016/j.jbc.2022.102842

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