A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity

Karyopherin-β2 (Kapβ2) is a nuclear-import receptor that recognizes proline-tyrosine nuclear localization signals of diverse cytoplasmic cargo for transport to the nucleus. Kapβ2 cargo includes several disease-linked RNA-binding proteins with prion-like domains, such as FUS, TAF15, EWSR1, hnRNPA1, a...

Descripción completa

Detalles Bibliográficos
Autores principales: Fare, Charlotte M., Rhine, Kevin, Lam, Andrew, Myong, Sua, Shorter, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860449/
https://www.ncbi.nlm.nih.gov/pubmed/36529289
http://dx.doi.org/10.1016/j.jbc.2022.102806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860449/
https://www.ncbi.nlm.nih.gov/pubmed/36529289
http://dx.doi.org/10.1016/j.jbc.2022.102806

Ejemplares similares