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A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity

Karyopherin-β2 (Kapβ2) is a nuclear-import receptor that recognizes proline-tyrosine nuclear localization signals of diverse cytoplasmic cargo for transport to the nucleus. Kapβ2 cargo includes several disease-linked RNA-binding proteins with prion-like domains, such as FUS, TAF15, EWSR1, hnRNPA1, a...

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Detalles Bibliográficos
Autores principales:	Fare, Charlotte M., Rhine, Kevin, Lam, Andrew, Myong, Sua, Shorter, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860449/ https://www.ncbi.nlm.nih.gov/pubmed/36529289 http://dx.doi.org/10.1016/j.jbc.2022.102806

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