PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation

Vascular aging is an independent risk factor for cardiovascular diseases, but the regulatory mechanism is not clearly understood. In this study, we found that endothelial PKR activity is elevated in aging aorta tissues, which is accompanied with increased endothelial cell hyperactivation, IL-1β and...

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Detalles Bibliográficos
Autores principales: Peng, Zhouyangfan, Tan, Xiqing, Xie, Liangpeng, Li, Ze, Zhou, Sufang, Li, Yapei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860489/
https://www.ncbi.nlm.nih.gov/pubmed/36691613
http://dx.doi.org/10.1016/j.isci.2022.105909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860489/
https://www.ncbi.nlm.nih.gov/pubmed/36691613
http://dx.doi.org/10.1016/j.isci.2022.105909

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