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The carboxyl-terminal TSP1-homology domain is the biologically active effector peptide of matricellular protein CCN5 that counteracts profibrotic CCN2

Cellular Communication Network (CCN) proteins have multimodular structures important for their roles in cellular responses associated with organ development and tissue homeostasis. CCN2 has previously been reported to be secreted as a preproprotein that requires proteolytic activation to release its...

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Detalles Bibliográficos
Autores principales: Zolfaghari, Sima, Kaasbøll, Ole Jørgen, Monsen, Vivi T., Sredic, Bojana, Hagelin, Else Marie V., Attramadal, Håvard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860493/
https://www.ncbi.nlm.nih.gov/pubmed/36529291
http://dx.doi.org/10.1016/j.jbc.2022.102803