DNA damage to bone marrow stromal cells by antileukemia drugs induces chemoresistance in acute myeloid leukemia via paracrine FGF10–FGFR2 signaling

Chemoresistance remains a major challenge in the current treatment of acute myeloid leukemia (AML). The bone marrow microenvironment (BMM) plays a complex role in protecting leukemia cells from chemotherapeutics, and the mechanisms involved are not fully understood. Antileukemia drugs kill AML cells...

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Detalles Bibliográficos
Autores principales: Yu, Shuang, Ye, Jingjing, Wang, Yingqiao, Lu, Ting, Liu, Yan, Liu, Na, Zhang, Jingru, Lu, Fei, Ma, Daoxin, Gale, Robert Peter, Ji, Chunyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860495/
https://www.ncbi.nlm.nih.gov/pubmed/36509141
http://dx.doi.org/10.1016/j.jbc.2022.102787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860495/
https://www.ncbi.nlm.nih.gov/pubmed/36509141
http://dx.doi.org/10.1016/j.jbc.2022.102787

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