Identification of New N-methyl-piperazine Chalcones as Dual MAO-B/AChE Inhibitors

Monoamine oxidase-B (MAO-B), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) have been considered target enzymes of depression and neurodegenerative diseases, including Alzheimer’s disease (AD). In this study, seventeen N-methyl-piperazine chalcones were synthesized, and their inhibito...

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Detalles Bibliográficos
Autores principales: El-Damasy, Ashraf K., Park, Jong Eun, Kim, Hyun Ji, Lee, Jinhyuk, Bang, Eun-Kyoung, Kim, Hoon, Keum, Gyochang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860728/
https://www.ncbi.nlm.nih.gov/pubmed/36678580
http://dx.doi.org/10.3390/ph16010083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860728/
https://www.ncbi.nlm.nih.gov/pubmed/36678580
http://dx.doi.org/10.3390/ph16010083

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