Selenylated Imidazo[1,2-a]pyridine Induces Cell Senescence and Oxidative Stress in Chronic Myeloid Leukemia Cells

Imidazo[1,2-a]pyridines (IPs) have been studied regarding drug development. The objective of this work was to evaluate the antileukemic capacity of IP derivatives by screening their ability as a pro-oxidant. IP derivatives were synthesized and oral bioavailability and toxicity were analyzed in silic...

Descripción completa

Detalles Bibliográficos
Autores principales: Burkner, Gabriella Teles, Dias, Dhébora Albuquerque, de Souza, Kamylla Fernanda Souza, de Araújo, Anna Júlia Papa, Basilio, Denise Caroline Luiz Soares, Jacobsen, Fernanda Tondello, de Moraes, Ana Carolina Rabello, Silva-Filho, Saulo Euclides, Cavalcante, Marcos Filipe de Oliveira, Moraes, Cassio Augusto de Oliveira, Saba, Sumbal, Macedo, Maria Lígia Rodrigues, Paredes-Gamero, Edgar Julian, Rafique, Jamal, Parisotto, Eduardo Benedetti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860887/
https://www.ncbi.nlm.nih.gov/pubmed/36677949
http://dx.doi.org/10.3390/molecules28020893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860887/
https://www.ncbi.nlm.nih.gov/pubmed/36677949
http://dx.doi.org/10.3390/molecules28020893

Ejemplares similares