Prospective Prediction of Dapaconazole Clinical Drug–Drug Interactions Using an In Vitro to In Vivo Extrapolation Equation and PBPK Modeling

This study predicted dapaconazole clinical drug–drug interactions (DDIs) over the main Cytochrome P450 (CYP) isoenzymes using static (in vitro to in vivo extrapolation equation, IVIVE) and dynamic (PBPK model) approaches. The in vitro inhibition of main CYP450 isoenzymes by dapaconazole in a human l...

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Detalles Bibliográficos
Autores principales: Antunes, Natalícia de Jesus, Moreira, Fernanda de Lima, Kipper, Karin, Couchman, Lewis, Lebre, Daniel Temponi, Johnston, Atholl, De Nucci, Gilberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861162/
https://www.ncbi.nlm.nih.gov/pubmed/36678526
http://dx.doi.org/10.3390/ph16010028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861162/
https://www.ncbi.nlm.nih.gov/pubmed/36678526
http://dx.doi.org/10.3390/ph16010028

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