Solving an Old Puzzle: Elucidation and Evaluation of the Binding Mode of Salvinorin A at the Kappa Opioid Receptor

The natural product Salvinorin A (SalA) was the first nitrogen-lacking agonist discovered for the opioid receptors and exhibits high selectivity for the kappa opioid receptor (KOR) turning SalA into a promising analgesic to overcome the current opioid crisis. Since SalA’s suffers from poor pharmacok...

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Detalles Bibliográficos
Autores principales: Puls, Kristina, Wolber, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861206/
https://www.ncbi.nlm.nih.gov/pubmed/36677775
http://dx.doi.org/10.3390/molecules28020718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861206/
https://www.ncbi.nlm.nih.gov/pubmed/36677775
http://dx.doi.org/10.3390/molecules28020718

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