Application of Box-Behnken Design in the Preparation, Optimization, and In-Vivo Pharmacokinetic Evaluation of Oral Tadalafil-Loaded Niosomal Film

Benign prostatic hyperplasia (BPH) affects about 90% of men whose ages are over 65. Tadalafil, a selective PDE-5 inhibitor, was approved by FDA for BPH, however, its poor aqueous solubility and bioavailability are considered major drawbacks. This work intended to develop and evaluate oral fast disso...

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Detalles Bibliográficos
Autores principales: Abla, Kawthar K., Mneimneh, Amina T., Allam, Ahmed N., Mehanna, Mohammed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861327/
https://www.ncbi.nlm.nih.gov/pubmed/36678802
http://dx.doi.org/10.3390/pharmaceutics15010173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861327/
https://www.ncbi.nlm.nih.gov/pubmed/36678802
http://dx.doi.org/10.3390/pharmaceutics15010173

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