The Anaesthetics Isoflurane and Xenon Reverse the Synaptotoxic Effects of Aβ(1–42) on Megf10-Dependent Astrocytic Synapse Elimination and Spine Density in Ex Vivo Hippocampal Brain Slices

It has been hypothesised that inhalational anaesthetics such as isoflurane (Iso) may trigger the pathogenesis of Alzheimer’s disease (AD), while the gaseous anaesthetic xenon (Xe) exhibits many features of a putative neuroprotective agent. Loss of synapses is regarded as one key cause of dementia in...

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Detalles Bibliográficos
Autores principales: Shi, Dai, Wong, Jaime K. Y., Zhu, Kaichuan, Noakes, Peter G., Rammes, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861496/
https://www.ncbi.nlm.nih.gov/pubmed/36674434
http://dx.doi.org/10.3390/ijms24020912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861496/
https://www.ncbi.nlm.nih.gov/pubmed/36674434
http://dx.doi.org/10.3390/ijms24020912

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