Interaction of a Homologous Series of Amphiphiles with P-glycoprotein in a Membrane Environment—Contributions of Polar and Non-Polar Interactions

The transport of drugs by efflux transporters in biomembranes limits their bioavailability and is a major determinant of drug resistance development by cancer cells and pathogens. A large number of chemically dissimilar drugs are transported, and despite extensive studies, the molecular determinants...

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Detalles Bibliográficos
Autores principales: Moreno, Maria João, Filipe, Hugo A. L., Cunha, Susana V. P., Ramos, Cristiana V., Martins, Patrícia A. T., Abel, Biebele, Loura, Luís M. S., Ambudkar, Suresh V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862096/
https://www.ncbi.nlm.nih.gov/pubmed/36678803
http://dx.doi.org/10.3390/pharmaceutics15010174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862096/
https://www.ncbi.nlm.nih.gov/pubmed/36678803
http://dx.doi.org/10.3390/pharmaceutics15010174

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