Physiologically Based Biopharmaceutics Modeling of Food Effect for Basmisanil: A Retrospective Case Study of the Utility for Formulation Bridging

Basmisanil, is a lipophilic drug substance, exhibiting poor solubility and good permeability (BCS class 2). A validated physiologically based biopharmaceutics model (PBBM) has been previously described for tablets dosed in the fed state. The PBBM captured the less than proportional increases in expo...

Descripción completa

Detalles Bibliográficos
Autores principales: Belubbi, Tejashree, Bassani, Davide, Stillhart, Cordula, Parrott, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862143/
https://www.ncbi.nlm.nih.gov/pubmed/36678820
http://dx.doi.org/10.3390/pharmaceutics15010191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862143/
https://www.ncbi.nlm.nih.gov/pubmed/36678820
http://dx.doi.org/10.3390/pharmaceutics15010191

Ejemplares similares