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Physiologically Based Biopharmaceutics Modeling of Food Effect for Basmisanil: A Retrospective Case Study of the Utility for Formulation Bridging

Basmisanil, is a lipophilic drug substance, exhibiting poor solubility and good permeability (BCS class 2). A validated physiologically based biopharmaceutics model (PBBM) has been previously described for tablets dosed in the fed state. The PBBM captured the less than proportional increases in expo...

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Detalles Bibliográficos
Autores principales:	Belubbi, Tejashree, Bassani, Davide, Stillhart, Cordula, Parrott, Neil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862143/ https://www.ncbi.nlm.nih.gov/pubmed/36678820 http://dx.doi.org/10.3390/pharmaceutics15010191

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