Chemical Synthesis and Biological Evaluation of 3-Substituted Estrone/Estradiol Derivatives as 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors Acting via a Reverse Orientation of the Natural Substrate Estrone

Estradiol (E2) plays an important role in the progression of diseases such as breast cancer and endometriosis. Inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), the enzyme that catalyzes the last step in the biosynthesis of the estrogenic hormone E2, therefore constitutes an interest...

Descripción completa

Detalles Bibliográficos
Autores principales: Ngueta, Adrien Djiemeny, Roy, Jenny, Maltais, René, Poirier, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862175/
https://www.ncbi.nlm.nih.gov/pubmed/36677690
http://dx.doi.org/10.3390/molecules28020632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862175/
https://www.ncbi.nlm.nih.gov/pubmed/36677690
http://dx.doi.org/10.3390/molecules28020632

Ejemplares similares