Oxy210, a Semi-Synthetic Oxysterol, Inhibits Profibrotic Signaling in Cellular Models of Lung and Kidney Fibrosis

Oxy210, a semi-synthetic oxysterol derivative, displays cell-selective inhibition of Hedgehog (Hh) and transforming growth factor beta (TGF-β) signaling in epithelial cells, fibroblasts, and macrophages as well as antifibrotic and anti-inflammatory efficacy in models of liver fibrosis. In the presen...

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Detalles Bibliográficos
Autores principales: Wang, Feng, Stappenbeck, Frank, Parhami, Farhad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862207/
https://www.ncbi.nlm.nih.gov/pubmed/36678611
http://dx.doi.org/10.3390/ph16010114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862207/
https://www.ncbi.nlm.nih.gov/pubmed/36678611
http://dx.doi.org/10.3390/ph16010114

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