Cargando…

The Role of Myeloperoxidase in Clozapine-Induced Inflammation: A Mechanistic Update for Idiosyncratic Drug-Induced Agranulocytosis

The risk of idiosyncratic drug-induced agranulocytosis (IDIAG) markedly constrains the use of clozapine, a neuroleptic with unparalleled efficacy. Most clozapine patients experience an early inflammatory response, likely a necessary step in IDIAG onset. However, most patients do not progress to IDIA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sernoskie, Samantha Christine, Jee, Alison, Uetrecht, Jack
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862306/ https://www.ncbi.nlm.nih.gov/pubmed/36674761 http://dx.doi.org/10.3390/ijms24021243

Ejemplares similares

Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis
por: Sernoskie, Samantha Christine, et al.
Publicado: (2021)

Idiosyncratic Drug-Induced Liver Injury: Mechanistic and Clinical Challenges
por: Jee, Alison, et al.
Publicado: (2021)

Drug-Induced Idiosyncratic Agranulocytosis - Infrequent but Dangerous
por: Rattay, Bernd, et al.
Publicado: (2021)

Idiosyncratic Drug-Induced Neutropenia and Agranulocytosis in Elderly Patients
por: Lorenzo-Villalba, Noel, et al.
Publicado: (2020)

Mechanistic Studies of Idiosyncratic DILI: Clinical Implications
por: Uetrecht, Jack
Publicado: (2019)

Clozapine-induced agranulocytosis
por: Mijovic, Aleksandar, et al.
Publicado: (2020)

Immune mechanisms of idiosyncratic drug-induced liver injury
por: Mak, Alastair, et al.
Publicado: (2017)

State of Art of Idiosyncratic Drug-Induced Neutropenia or Agranulocytosis, with a Focus on Biotherapies
por: Andrès, Emmanuel, et al.
Publicado: (2019)

Late Onset Clozapine Induced Agranulocytosis
por: Velayudhan, Rajmohan, et al.
Publicado: (2014)

Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues
por: Teschke, Rolf, et al.
Publicado: (2021)

CLOZAPINE-INDUCED AGRANULOCYTOSIS AND USE OF G-CSF
por: Srinivasan, T.N., et al.
Publicado: (1998)

AGRANULOCYTOSIS DURING CLOZAPINE THERAPY
por: Jagadheesan, K., et al.
Publicado: (2000)

Idiosyncratic Drug Reactions: A 35-Year Chemical Research in Toxicology Perspective
por: Uetrecht, Jack
Publicado: (2022)

Establishing the characteristics of an effective pharmacogenetic test for clozapine-induced agranulocytosis
por: Verbelen, M, et al.
Publicado: (2015)

Deferiprone‐induced agranulocytosis: 20 years of clinical observations
por: Tricta, Fernando, et al.
Publicado: (2016)

Pharmacogenomics of Clozapine-induced agranulocytosis: a systematic review and meta-analysis
por: Islam, Farhana, et al.
Publicado: (2022)

Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis
por: Numata, Shusuke, et al.
Publicado: (2018)

Idiosyncratic Drug-Induced Severe Neutropenia and Agranulocytosis in Elderly Patients (≥75 years): A Monocentric Cohort Study of 61 Cases
por: Mourot-Cottet, Rachel, et al.
Publicado: (2016)

Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury
por: Kim, Seung-Hyun, et al.
Publicado: (2016)

Leukopenia and agranulocytosis in atypical antipsychotic treatment - besides clozapine
por: Jorge, B., et al.
Publicado: (2021)

Testing Possible Risk Factors for Idiosyncratic Drug-Induced Liver Injury Using an Amodiaquine Mouse Model and Co-treatment with 1-Methyl-d-Tryptophan or Acetaminophen
por: Cho, Tiffany, et al.
Publicado: (2021)

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles
por: Goldstein, Jacqueline I, et al.
Publicado: (2014)

Mechanistic Understanding of Idiosyncratic Drug-Induced Hepatotoxicity Using Co-Cultures of Hepatocytes and Macrophages
por: Villanueva-Badenas, Estela, et al.
Publicado: (2023)

Ceftriaxone-Induced Reversible Agranulocytosis: A Case Report and Review of Drug-Induced Agranulocytosis
por: Munir, Farrukh, et al.
Publicado: (2022)

Low-Dose Clozapine-Induced Agranulocytosis in Patients with Movement Disorders—Retrospective Study from India
por: Choudhury, Supriyo, et al.
Publicado: (2021)

A Case of Sudden Very Late Onset of Severe Clozapine-induced Agranulocytosis Following an Influenza Vaccine
por: Jean, Soluny, et al.
Publicado: (2019)

Considerations of HLA, Renal Failure, Valproic Acid Use, and Current Treatment Guidelines in Clozapine-Induced Agranulocytosis
por: Sussman, Melissa, et al.
Publicado: (2021)

Carbimazole-induced agranulocytosis
por: Mohan, Anisha, et al.
Publicado: (2015)

Distinctive pattern of neutrophil count change in clozapine-associated, life-threatening agranulocytosis
por: Taylor, David, et al.
Publicado: (2022)

Microphysiological Models for Mechanistic-Based Prediction of Idiosyncratic DILI
por: Stern, Sydney, et al.
Publicado: (2023)

SAT-600 Relapse of Agranulocytosis after Recovery of Methimazole-Induced Agranulocytosis
por: Choi, Dughyun, et al.
Publicado: (2019)

Metabolomic Analysis of Pediatric Patients with Idiosyncratic Drug-Induced Liver Injury According to the Updated RUCAM
por: Andújar-Vera, Francisco, et al.
Publicado: (2023)

Exploring Off-Targets and Off-Systems for Adverse Drug Reactions via Chemical-Protein Interactome — Clozapine-Induced Agranulocytosis as a Case Study
por: Yang, Lun, et al.
Publicado: (2011)

Antithyroid Drug-Induced Agranulocytosis: A Case Report
por: MacKay, Micaela, et al.
Publicado: (2023)

Agranulocytosis Induced by Sinomenine Hydrochloride
por: Chen, Juerong, et al.
Publicado: (2017)

HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry
por: Konte, Bettina, et al.
Publicado: (2021)

Antithyroid Drug-Induced Agranulocytosis: State of the Art on Diagnosis and Management
por: Vicente, Nuno, et al.
Publicado: (2017)

Idiosyncratic drug‐induced liver injury: A short review
por: Yamashita, Yo‐ichi, et al.
Publicado: (2017)

Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids
por: Sundaram, Suneha, et al.
Publicado: (2020)

Neutropenia and agranulocytosis during treatment of schizophrenia with clozapine versus other antipsychotics: an observational study in Iceland
por: Ingimarsson, Oddur, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_3j0qj18olri5gf90vg5ml1rbl5