Heterogeneous Development of β-Cell Populations in Diabetes-Resistant and -Susceptible Mice

Progressive dysfunction and failure of insulin-releasing β-cells are a hallmark of type 2 diabetes (T2D). To study mechanisms of β-cell loss in T2D, we performed islet single-cell RNA sequencing of two obese mouse strains differing in their diabetes susceptibility. With mice on a control diet, we id...

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Detalles Bibliográficos
Autores principales: Gottmann, Pascal, Speckmann, Thilo, Stadion, Mandy, Zuljan, Erika, Aga, Heja, Sterr, Michael, Büttner, Maren, Santos, Patrícia Martínez, Jähnert, Markus, Bornstein, Stefan R., Theis, Fabian J., Lickert, Heiko, Schürmann, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2022
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862397/
https://www.ncbi.nlm.nih.gov/pubmed/35771990
http://dx.doi.org/10.2337/db21-1030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862397/
https://www.ncbi.nlm.nih.gov/pubmed/35771990
http://dx.doi.org/10.2337/db21-1030

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