C3-Symmetric Ligands in Drug Design: When the Target Controls the Aesthetics of the Drug

A number of proteins are able to adopt a homotrimeric spatial conformation. Among these structures, this feature appears as crucial for biologic targets, since it facilitates the design of C3-symmetric ligands that are especially suitable for displaying optimized ligand–target interactions and thera...

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Detalles Bibliográficos
Autores principales: Antonijevic, Mirjana, Rochais, Christophe, Dallemagne, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862528/
https://www.ncbi.nlm.nih.gov/pubmed/36677739
http://dx.doi.org/10.3390/molecules28020679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862528/
https://www.ncbi.nlm.nih.gov/pubmed/36677739
http://dx.doi.org/10.3390/molecules28020679

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