Assessment of Thermal Stability of Mutant p53 Proteins via Differential Scanning Fluorimetry

The p53 protein is a transcription factor that preserves the integrity of the genome. The TP53 gene has inactivating mutations in about 50% of all human cancers. Some missense mutations lead to decreased thermal stability in the p53 protein, its unfolding and aggregation under physiological conditio...

Descripción completa

Detalles Bibliográficos
Autores principales: Khadiullina, Raniya, Mirgayazova, Regina, Davletshin, Damir, Khusainova, Elvina, Chasov, Vitaly, Bulatov, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862671/
https://www.ncbi.nlm.nih.gov/pubmed/36675980
http://dx.doi.org/10.3390/life13010031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862671/
https://www.ncbi.nlm.nih.gov/pubmed/36675980
http://dx.doi.org/10.3390/life13010031

Ejemplares similares