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Assessment of Thermal Stability of Mutant p53 Proteins via Differential Scanning Fluorimetry

The p53 protein is a transcription factor that preserves the integrity of the genome. The TP53 gene has inactivating mutations in about 50% of all human cancers. Some missense mutations lead to decreased thermal stability in the p53 protein, its unfolding and aggregation under physiological conditio...

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Detalles Bibliográficos
Autores principales:	Khadiullina, Raniya, Mirgayazova, Regina, Davletshin, Damir, Khusainova, Elvina, Chasov, Vitaly, Bulatov, Emil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862671/ https://www.ncbi.nlm.nih.gov/pubmed/36675980 http://dx.doi.org/10.3390/life13010031

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