Neuronal Dot1l Activity Acts as a Mitochondrial Gene-Repressor Associated with Human Brain Aging via H3K79 Hypermethylation

Methylation of histone 3 at lysine 79 (H3K79) and its catalyst, a disrupter of telomeric silencing (DOT1l), have been coupled to multiple forms of stress, such as bioenergetic and ER challenges. However, studies on H3K79 methylation and Dot1l in the (aging) brain and neurons are limited. This, toget...

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Detalles Bibliográficos
Autores principales: Van Heesbeen, Hendrikus J., Von Oerthel, Lars, De Vries, Paul M., Wagemans, Cindy M. R. J., Smidt, Marten P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862808/
https://www.ncbi.nlm.nih.gov/pubmed/36674903
http://dx.doi.org/10.3390/ijms24021387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862808/
https://www.ncbi.nlm.nih.gov/pubmed/36674903
http://dx.doi.org/10.3390/ijms24021387

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