Diclofenac Disrupts the Circadian Clock and through Complex Cross-Talks Aggravates Immune-Mediated Liver Injury—A Repeated Dose Study in Minipigs for 28 Days

Diclofenac effectively reduces pain and inflammation; however, its use is associated with hepato- and nephrotoxicity. To delineate mechanisms of injury, we investigated a clinically relevant (3 mg/kg) and high-dose (15 mg/kg) in minipigs for 4 weeks. Initially, serum biochemistries and blood-smears...

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Detalles Bibliográficos
Autores principales: Selvaraj, Saravanakumar, Oh, Jung-Hwa, Yoon, Seokjoo, Borlak, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863319/
https://www.ncbi.nlm.nih.gov/pubmed/36674967
http://dx.doi.org/10.3390/ijms24021445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863319/
https://www.ncbi.nlm.nih.gov/pubmed/36674967
http://dx.doi.org/10.3390/ijms24021445

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