Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs

PROteolysis TArgeting Chimaeras (PROTACs) offer new opportunities in modern medicine by targeting proteins that are undruggable to classic inhibitors. However, due to their hydrophobic structure, PROTACs typically suffer from low solubility, and oral bioavailability remains challenging. At the same...

Descripción completa

Detalles Bibliográficos
Autores principales: Pöstges, Florian, Kayser, Kevin, Appelhaus, Jan, Monschke, Marius, Gütschow, Michael, Steinebach, Christian, Wagner, Karl G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863516/
https://www.ncbi.nlm.nih.gov/pubmed/36678785
http://dx.doi.org/10.3390/pharmaceutics15010156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863516/
https://www.ncbi.nlm.nih.gov/pubmed/36678785
http://dx.doi.org/10.3390/pharmaceutics15010156

Ejemplares similares