Isomeric Activity Cliffs—A Case Study for Fluorine Substitution of Aminergic G Protein-Coupled Receptor Ligands

Currently, G protein-coupled receptors (GPCRs) constitute a significant group of membrane-bound receptors representing more than 30% of therapeutic targets. Fluorine is commonly used in designing highly active biological compounds, as evidenced by the steadily increasing number of drugs by the Food...

Descripción completa

Detalles Bibliográficos
Autores principales: Pietruś, Wojciech, Kurczab, Rafał, Warszycki, Dawid, Bojarski, Andrzej J., Bajorath, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863698/
https://www.ncbi.nlm.nih.gov/pubmed/36677547
http://dx.doi.org/10.3390/molecules28020490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863698/
https://www.ncbi.nlm.nih.gov/pubmed/36677547
http://dx.doi.org/10.3390/molecules28020490

Ejemplares similares