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Isomeric Activity Cliffs—A Case Study for Fluorine Substitution of Aminergic G Protein-Coupled Receptor Ligands

Currently, G protein-coupled receptors (GPCRs) constitute a significant group of membrane-bound receptors representing more than 30% of therapeutic targets. Fluorine is commonly used in designing highly active biological compounds, as evidenced by the steadily increasing number of drugs by the Food...

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Detalles Bibliográficos
Autores principales:	Pietruś, Wojciech, Kurczab, Rafał, Warszycki, Dawid, Bojarski, Andrzej J., Bajorath, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863698/ https://www.ncbi.nlm.nih.gov/pubmed/36677547 http://dx.doi.org/10.3390/molecules28020490

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