Natural Steroidal Lactone Induces G1/S Phase Cell Cycle Arrest and Intrinsic Apoptotic Pathway by Up-Regulating Tumor Suppressive miRNA in Triple-Negative Breast Cancer Cells

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with minimal treatment options. In the present work, Withaferin A (WA), a natural steroidal lactone found in Withania somnifera (Solanaceae), was studied to deduce the miRNA expression modulation mediated anticancer mode...

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Detalles Bibliográficos
Autores principales: Shuaib, Mohd, Prajapati, Kumari Sunita, Gupta, Sanjay, Kumar, Shashank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863888/
https://www.ncbi.nlm.nih.gov/pubmed/36676955
http://dx.doi.org/10.3390/metabo13010029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863888/
https://www.ncbi.nlm.nih.gov/pubmed/36676955
http://dx.doi.org/10.3390/metabo13010029

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