Efficacy of Dabrafenib and Trametinib in a Patient with Squamous-Cell Carcinoma, with Mutation p.D594G in BRAF and p.R461* in NF1 Genes—A Case Report with Literature Review

The 3rd class of BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase) variants including G466, D594, and A581 mutations cause kinase death or impaired kinase activity. It is unlikely that RAF (Raf Proto-Oncogene, Serine/Threonine Kinase) inhibitors suppress ERK (Extracellular Signal-Regulated Kinase...

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Detalles Bibliográficos
Autores principales: Grenda, Anna, Krawczyk, Pawel, Targowska-Duda, Katarzyna M., Kieszko, Robert, Paśnik, Iwona, Milanowski, Janusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864135/
https://www.ncbi.nlm.nih.gov/pubmed/36674722
http://dx.doi.org/10.3390/ijms24021195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864135/
https://www.ncbi.nlm.nih.gov/pubmed/36674722
http://dx.doi.org/10.3390/ijms24021195

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