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Reduction-Responsive Stearyl Alcohol-Cabazitaxel Prodrug Nanoassemblies for Cancer Chemotherapy

Cabazitaxel (CTX) has distinct therapeutic merits for advanced and metastatic cancer. However, the present clinical formulation (Jevtana(®)) has several defects, especially for undesirable tumor-targeting and serious side effects, greatly limiting the therapeutic efficacy. Small-molecule prodrug-bas...

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Detalles Bibliográficos
Autores principales: Liu, Yuting, Wang, Xinhui, Wang, Zhe, Liao, Rui, Qiu, Qian, Wang, Yuequan, Luo, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864162/
https://www.ncbi.nlm.nih.gov/pubmed/36678891
http://dx.doi.org/10.3390/pharmaceutics15010262