Discovery of a Novel Trifluoromethyl Diazirine Inhibitor of SARS-CoV-2 M(pro)

SARS-CoV-2 M(pro) is a chymotrypsin-like cysteine protease playing a relevant role during the replication and infectivity of SARS-CoV-2, the coronavirus responsible for COVID-19. The binding site of M(pro) is characterized by the presence of a catalytic Cys145 which carries out the hydrolytic activi...

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Detalles Bibliográficos
Autores principales: Citarella, Andrea, Moi, Davide, Pedrini, Martina, Pérez-Peña, Helena, Pieraccini, Stefano, Stagno, Claudio, Micale, Nicola, Schirmeister, Tanja, Sibille, Giulia, Gribaudo, Giorgio, Silvani, Alessandra, Passarella, Daniele, Giannini, Clelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864213/
https://www.ncbi.nlm.nih.gov/pubmed/36677572
http://dx.doi.org/10.3390/molecules28020514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864213/
https://www.ncbi.nlm.nih.gov/pubmed/36677572
http://dx.doi.org/10.3390/molecules28020514

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