Dimeric Lectin Chimeras as Novel Candidates for Gb3-Mediated Transcytotic Drug Delivery through Cellular Barriers

Receptor-mediated transcytosis is an elegant and promising strategy for drug delivery across biological barriers. Here, we describe a novel ligand–receptor pair based on a dimeric, engineered derivative of the Pseudomonas aeruginosa lectin LecA, here termed Di-LecA, and the host cell glycosphingolip...

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Detalles Bibliográficos
Autores principales: Xu, Maokai, Antonova, Maria, Salavei, Pavel, Illek, Katharina, Meléndez, Ana Valeria, Omidvar, Ramin, Thuenauer, Roland, Makshakova, Olga, Römer, Winfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864468/
https://www.ncbi.nlm.nih.gov/pubmed/36678854
http://dx.doi.org/10.3390/pharmaceutics15010225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864468/
https://www.ncbi.nlm.nih.gov/pubmed/36678854
http://dx.doi.org/10.3390/pharmaceutics15010225

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