Cargando…

Dimeric Lectin Chimeras as Novel Candidates for Gb3-Mediated Transcytotic Drug Delivery through Cellular Barriers

Receptor-mediated transcytosis is an elegant and promising strategy for drug delivery across biological barriers. Here, we describe a novel ligand–receptor pair based on a dimeric, engineered derivative of the Pseudomonas aeruginosa lectin LecA, here termed Di-LecA, and the host cell glycosphingolip...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Maokai, Antonova, Maria, Salavei, Pavel, Illek, Katharina, Meléndez, Ana Valeria, Omidvar, Ramin, Thuenauer, Roland, Makshakova, Olga, Römer, Winfried
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864468/ https://www.ncbi.nlm.nih.gov/pubmed/36678854 http://dx.doi.org/10.3390/pharmaceutics15010225

Ejemplares similares

Differential recognition of lipid domains by two Gb3-binding lectins
por: Schubert, Thomas, et al.
Publicado: (2020)

A Shiga Toxin B-Subunit-Based Lectibody Boosts T Cell Cytotoxicity towards Gb3-Positive Cancer Cells
por: Tomisch, Jana, et al.
Publicado: (2023)

Structural Diversities of Lectins Binding to the Glycosphingolipid Gb3
por: Siukstaite, Lina, et al.
Publicado: (2021)

Novel lectin-based chimeric antigen receptors target Gb3-positive tumour cells
por: Meléndez, Ana Valeria, et al.
Publicado: (2022)

Novel perspectives on the transcytotic route in osteoclasts
por: Hirvonen, Mirkka J, et al.
Publicado: (2013)

The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa
por: Brandel, Annette, et al.
Publicado: (2021)

A transcytotic transport mechanism across the tympanic membrane
por: Kurabi, Arwa, et al.
Publicado: (2022)

The Lectin LecB Induces Patches with Basolateral Characteristics at the Apical Membrane to Promote Pseudomonas aeruginosa Host Cell Invasion
por: Thuenauer, Roland, et al.
Publicado: (2022)

Rab17 regulates apical delivery of hepatic transcytotic vesicles
por: Striz, Anneliese C., et al.
Publicado: (2018)

Pseudomonas aeruginosa lectin LecB inhibits tissue repair processes by triggering β-catenin degradation
por: Cott, Catherine, et al.
Publicado: (2016)

The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3
por: Notova, Simona, et al.
Publicado: (2022)

The Pseudomonas aeruginosa Lectin LecB Causes Integrin Internalization and Inhibits Epithelial Wound Healing
por: Thuenauer, Roland, et al.
Publicado: (2020)

Humoral Immune Response of Mice against a Vaccine Candidate Composed of a Chimera of gB of Bovine Alphaherpesviruses 1 and 5
por: Quintero Barbosa, Juan Sebastian, et al.
Publicado: (2023)

The blood–brain barrier after stroke: Structural studies and the role of transcytotic vesicles
por: Haley, Michael J, et al.
Publicado: (2016)

A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death
por: Rosato, Francesca, et al.
Publicado: (2022)

The Lectin LecA Sensitizes the Human Stretch-Activated Channel TREK-1 but Not Piezo1 and Binds Selectively to Cardiac Non-myocytes
por: Darkow, Elisa, et al.
Publicado: (2020)

Thermal fluctuations of the lipid membrane determine particle uptake into Giant Unilamellar Vesicles
por: Ayala, Yareni A., et al.
Publicado: (2023)

Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons
Publicado: (1995)

Segregation of Glucosylceramide and Sphingomyelin Occurs in the Apical to Basolateral Transcytotic Route in HepG2 Cells
por: van IJzendoorn, Sven C.D., et al.
Publicado: (1997)

Sorting Mechanisms Regulating Membrane Protein Traffic in the Apical Transcytotic Pathway of Polarized MDCK Cells
por: Gibson, A., et al.
Publicado: (1998)

The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity
por: Tzaban, Salit, et al.
Publicado: (2009)

Bacterial lectin BambL acts as a B cell superantigen
por: Frensch, Marco, et al.
Publicado: (2021)

A microfluidic biochip for locally confined stimulation of cells within an epithelial monolayer
por: Thuenauer, Roland, et al.
Publicado: (2018)

Synchronizing Protein Traffic to the Primary Cilium
por: Stroukov, Wladislaw, et al.
Publicado: (2019)

Catfish Egg Lectin Enhances the Cytotoxicity of Sunitinib on Gb3-Expressing Renal Cancer Cells
por: Ito, Jun, et al.
Publicado: (2023)

Lectin-mediated protocell crosslinking to mimic cell-cell junctions and adhesion
por: Villringer, Sarah, et al.
Publicado: (2018)

Extending Janus lectins architecture: Characterization and application to protocells
por: Notova, Simona, et al.
Publicado: (2022)

Aquaporin 5 Expression in Mouse Mammary Gland Cells Is Not Driven by Promoter Methylation
por: Arbeithuber, Barbara, et al.
Publicado: (2015)

BanLec-eGFP Chimera as a Tool for Evaluation of Lectin Binding to High-Mannose Glycans on Microorganisms
por: Lopandić, Zorana, et al.
Publicado: (2021)

Algal Lectins as Potential HIV Microbicide Candidates
por: Huskens, Dana, et al.
Publicado: (2012)

Regulation of Intersubunit Interactions in Homotetramer of Glyceraldehyde-3-Phosphate Dehydrogenases upon Its Immobilization in Protein—Kappa-Carrageenan Gels
por: Makshakova, Olga, et al.
Publicado: (2023)

The search for the chimera
por: Randi, J
Publicado: (1991)

Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells
por: Ribeiro, João P., et al.
Publicado: (2018)

The Two Sweet Sides of Janus Lectin Drive Crosslinking of Liposomes to Cancer Cells and Material Uptake
por: Siukstaite, Lina, et al.
Publicado: (2021)

UV-B promotes flavonoid biosynthesis in Ginkgo biloba by inducing the GbHY5-GbMYB1-GbFLS module
por: Liu, Sian, et al.
Publicado: (2023)

Enzymatic Glyco-Modification of Synthetic Membrane Systems
por: Jabeguero, Dylan, et al.
Publicado: (2023)

Network Analysis Reveals the Recognition Mechanism for Dimer Formation of Bulb-type Lectins
por: Zhao, Yunjie, et al.
Publicado: (2017)

Uptake of Marasmius oreades agglutinin disrupts integrin-dependent cell adhesion
por: Juillot, Samuel, et al.
Publicado: (2016)

Strain-transcending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2
por: Krishnarjuna, Bankala, et al.
Publicado: (2016)

MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt’s Lymphoma Cells to Trigger Apoptosis through Multiple Pathways
por: Hasan, Imtiaj, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_e3j6hpth72tcockq9ts90e96r7