An Atypical, Staged Cell Death Pathway Induced by Depletion of SNARE-Proteins MUNC18-1 or Syntaxin-1

The presynaptic proteins MUNC18-1, syntaxin-1, and SNAP25 drive SNARE-mediated synaptic vesicle fusion and are also required for neuronal viability. Their absence triggers rapid, cell-autonomous, neuron-specific degeneration, unrelated to synaptic vesicle deficits. The underlying cell death pathways...

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Detalles Bibliográficos
Autores principales: Feringa, Femke M., van Berkel, Annemiek A., Nair, Anushka, Verhage, Matthijs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864589/
https://www.ncbi.nlm.nih.gov/pubmed/36517239
http://dx.doi.org/10.1523/JNEUROSCI.0611-22.2022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864589/
https://www.ncbi.nlm.nih.gov/pubmed/36517239
http://dx.doi.org/10.1523/JNEUROSCI.0611-22.2022

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