Identification of Lignan Compounds as New 6-Phosphogluconate Dehydrogenase Inhibitors for Lung Cancer

Targeting pentose phosphate pathway (PPP) enzymes has emerged as a promising strategy to combat cancer. 6-Phosphogluconate dehydrogenase (6-PGD), the third critical enzyme of the PPP, catalyzes oxidative decarboxylation of 6-phosphogluconate (6-PG) to produce ribulose-5-phosphate (Ru-5-P) and CO2. O...

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Detalles Bibliográficos
Autores principales: Khan, Gul Bushra, Qasim, Muhammad, Rasul, Azhar, Ashfaq, Usman Ali, Alnuqaydan, Abdullah M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864769/
https://www.ncbi.nlm.nih.gov/pubmed/36676959
http://dx.doi.org/10.3390/metabo13010034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864769/
https://www.ncbi.nlm.nih.gov/pubmed/36676959
http://dx.doi.org/10.3390/metabo13010034

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