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AmyP53 Prevents the Formation of Neurotoxic β-Amyloid Oligomers through an Unprecedent Mechanism of Interaction with Gangliosides: Insights for Alzheimer’s Disease Therapy

A broad range of data identify Ca(2+)-permeable amyloid pores as the most neurotoxic species of Alzheimer’s β-amyloid peptide (Aβ(1–42)). Following the failures of clinical trials targeting amyloid plaques by immunotherapy, a consensus is gradually emerging to change the paradigm, the strategy, and...

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Detalles Bibliográficos
Autores principales: Azzaz, Fodil, Chahinian, Henri, Yahi, Nouara, Fantini, Jacques, Di Scala, Coralie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864847/
https://www.ncbi.nlm.nih.gov/pubmed/36675271
http://dx.doi.org/10.3390/ijms24021760