Improved Metal-Free Approach for the Synthesis of Protected Thiol Containing Thymidine Nucleoside Phosphoramidite and Its Application for the Synthesis of Ligatable Oligonucleotide Conjugates

Oligonucleotide conjugates are versatile scaffolds that can be applied in DNA-based screening platforms and ligand display or as therapeutics. Several different chemical approaches are available for functionalizing oligonucleotides, which are often carried out on the 5′ or 3′ end. Modifying oligonuc...

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Detalles Bibliográficos
Autores principales: Kupihár, Zoltán, Ferenc, Györgyi, Petrovicz, Vencel L., Fáy, Viktória R., Kovács, Lajos, Martinek, Tamás A., Hegedüs, Zsófia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865093/
https://www.ncbi.nlm.nih.gov/pubmed/36678876
http://dx.doi.org/10.3390/pharmaceutics15010248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865093/
https://www.ncbi.nlm.nih.gov/pubmed/36678876
http://dx.doi.org/10.3390/pharmaceutics15010248

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