Cargando…

Improved Metal-Free Approach for the Synthesis of Protected Thiol Containing Thymidine Nucleoside Phosphoramidite and Its Application for the Synthesis of Ligatable Oligonucleotide Conjugates

Oligonucleotide conjugates are versatile scaffolds that can be applied in DNA-based screening platforms and ligand display or as therapeutics. Several different chemical approaches are available for functionalizing oligonucleotides, which are often carried out on the 5′ or 3′ end. Modifying oligonuc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kupihár, Zoltán, Ferenc, Györgyi, Petrovicz, Vencel L., Fáy, Viktória R., Kovács, Lajos, Martinek, Tamás A., Hegedüs, Zsófia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865093/ https://www.ncbi.nlm.nih.gov/pubmed/36678876 http://dx.doi.org/10.3390/pharmaceutics15010248

Ejemplares similares

Analytical and Structural Studies for the Investigation of Oxidative Stress in Guanine Oligonucleotides
por: Ferenc, Györgyi, et al.
Publicado: (2020)

Tandem oligonucleotide synthesis using linker phosphoramidites
por: Pon, Richard T., et al.
Publicado: (2005)

Synthesis of Backbone-Modified Morpholino Oligonucleotides Using Phosphoramidite Chemistry
por: Paul, Sibasish, et al.
Publicado: (2023)

On-demand synthesis of phosphoramidites
por: Sandahl, Alexander F., et al.
Publicado: (2021)

Synthesis of Substituted Cy5 Phosphoramidite Derivatives and Their Incorporation into Oligonucleotides Using Automated DNA Synthesis
por: Meares, Adam, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of Triazolyl 13α-Estrone–Nucleoside Bioconjugates
por: Bodnár, Brigitta, et al.
Publicado: (2016)

A Study on Synthesis and Upscaling of 2′-O-AECM-5-methyl Pyrimidine Phosphoramidites for Oligonucleotide Synthesis
por: Karalė, Kristina, et al.
Publicado: (2021)

NAA-modified DNA oligonucleotides with zwitterionic backbones: stereoselective synthesis of A–T phosphoramidite building blocks
por: Schmidtgall, Boris, et al.
Publicado: (2015)

Proline-based Phosphoramidite Reagents for the Reductive Ligation of S-Nitrosothiols
por: Park, Chung-Min, et al.
Publicado: (2016)

A strongly pairing fifth base: oligonucleotides with a C-nucleoside replacing thymidine
por: Walter, Tanja J, et al.
Publicado: (2018)

Preparation of trinucleotide phosphoramidites as synthons for the synthesis of gene libraries
por: Suchsland, Ruth, et al.
Publicado: (2018)

A General Synthesis of C8-Arylpurine Phosphoramidites
por: Vongsutilers, Vorasit, et al.
Publicado: (2009)

Arylethynyl- or Alkynyl-Linked Pyrimidine and 7-Deazapurine 2′-Deoxyribonucleoside 3′-Phosphoramidites for Chemical Synthesis of Hypermodified Hydrophobic Oligonucleotides
por: Jestřábová, Ivana, et al.
Publicado: (2023)

Facile synthesis of a 3-deazaadenosine phosphoramidite for RNA solid-phase synthesis
por: Mairhofer, Elisabeth, et al.
Publicado: (2016)

Development of Phosphoramidite Reagents for the Synthesis of Base-Labile Oligonucleotides Modified with a Linear Aminoalkyl and Amino-PEG Linker at the 3′-End
por: Osawa, Takashi, et al.
Publicado: (2022)

Synthesis of phosphoramidites of isoGNA, an isomer of glycerol nucleic acid
por: Kim, Keunsoo, et al.
Publicado: (2014)

Biocatalytic Synthesis of Antiviral Nucleosides, Cyclic Dinucleotides, and Oligonucleotide Therapies
por: Van Giesen, Kyle J. D., et al.
Publicado: (2022)

Synthesis of coumarin or ferrocene labeled nucleosides via Staudinger ligation
por: Kosiova, Ivana, et al.
Publicado: (2006)

Synthesis of N(4)-acetylated 3-methylcytidine phosphoramidites for RNA solid-phase synthesis
por: Moreno, Sarah, et al.
Publicado: (2022)

Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries
por: Roy, Subhadeep, et al.
Publicado: (2013)

Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry
por: Johnston, C., et al.
Publicado: (2021)

Synthesis of a Morpholino Nucleic Acid (MNA)-Uridine Phosphoramidite, and Exon Skipping Using MNA/2′-O-Methyl Mixmer Antisense Oligonucleotide
por: Chen, Suxiang, et al.
Publicado: (2016)

Synthesis and characterization of oligonucleotides containing 2′-fluorinated thymidine glycol as inhibitors of the endonuclease III reaction
por: Doi, Yusuke, et al.
Publicado: (2006)

Understanding p300-transcription factor interactions using sequence variation and hybridization
por: Hóbor, Fruzsina, et al.
Publicado: (2022)

Phosphoramidite building blocks with protected nitroxides for the synthesis of spin-labeled DNA and RNA
por: Weinrich, Timo, et al.
Publicado: (2018)

The synthesis of (15)N(7)-Hoogsteen face-labeled adenosine phosphoramidite for solid-phase RNA synthesis
por: Neuner, Sandro, et al.
Publicado: (2016)

THYMIDINE TRIPHOSPHATE SYNTHESIS IN TETRAHYMENA : I. Studies on Thymidine Kinase
por: Shoup, G. D., et al.
Publicado: (1966)

Synthesis and Structural Characterization of Stable Branched DNA G-Quadruplexes Using the Trebler Phosphoramidite
por: Ferreira, Rubén, et al.
Publicado: (2012)

Novel Method of Synthesis of 5''-Phosphate 2'-O-ribosyl-ribonucleosides and Their 3'-Phosphoramidites
por: Chmielewski, Marcin K., et al.
Publicado: (2013)

A Trisbenzimidazole Phosphoramidite Building Block Enables High-Yielding Syntheses of RNA-Cleaving Oligonucleotide Conjugates
por: Zellmann, Felix, et al.
Publicado: (2020)

Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation
por: Dastpeyman, Mohadeseh, et al.
Publicado: (2021)

Thymidine Analogues for Tracking DNA Synthesis
por: Cavanagh, Brenton L., et al.
Publicado: (2011)

Lipid-linked nucleoside triphosphates for enzymatic synthesis of hydrophobic oligonucleotides with enhanced membrane anchoring efficiency
por: Kodr, David, et al.
Publicado: (2023)

Synthesis of Oligonucleotides Carrying Thiol Groups Using a Simple Reagent Derived from Threoninol
por: Pérez-Rentero, Sonia, et al.
Publicado: (2012)

Practical synthesis of N-(di-n-butylamino)methylene-protected 2-aminopurine riboside phosphoramidite for RNA solid-phase synthesis
por: Neuner, Eva, et al.
Publicado: (2019)

Synthesis and Characterization of Privileged Monodentate Phosphoramidite Ligands and Chiral Brønsted Acids Derived from d-Mannitol
por: Al-Majid, Abdullah Mohammed A., et al.
Publicado: (2012)

Efficient access to N-trifluoroacetylated 2′-amino-2′-deoxyadenosine phosphoramidite for RNA solid-phase synthesis
por: Falschlunger, Christoph, et al.
Publicado: (2019)

An Improved Approach for Practical Synthesis of 5-Hydroxymethyl-2′-deoxycytidine (5hmdC) Phosphoramidite and Triphosphate
por: Yang, Dong-Zhao, et al.
Publicado: (2022)

Improved Synthesis of Phosphoramidite-Protected N(6)-Methyladenosine via BOP-Mediated S(N)Ar Reaction
por: Shishodia, Shifali, et al.
Publicado: (2020)

Quick Access to Nucleobase-Modified Phosphoramidites for the Synthesis of Oligoribonucleotides Containing Post-Transcriptional Modifications and Epitranscriptomic Marks
por: Ziemkiewicz, Kamil, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ogs8m083b304gj9igflab0nscv