9-N-n-alkyl Berberine Derivatives: Hypoglycemic Activity Evaluation

Several novel 9-N-n-alkyl derivatives of berberine (C5, C7, C10, C12) were synthesized. They were analyzed in vitro and in vivo for their hypoglycemic activity. In vitro studies showed that the derivatives with shorter alkyl substitutes at concentrations ranging from 2.5 to 10 μM were able to stimul...

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Detalles Bibliográficos
Autores principales: Khvostov, Mikhail V., Gladkova, Elizaveta D., Borisov, Sergey A., Fedotova, Marina S., Zhukova, Nataliya A., Marenina, Mariya K., Meshkova, Yulia V., Valutsa, Nicolae, Luzina, Olga A., Tolstikova, Tatiana G., Salakhutdinov, Nariman F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865096/
https://www.ncbi.nlm.nih.gov/pubmed/36678673
http://dx.doi.org/10.3390/pharmaceutics15010044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865096/
https://www.ncbi.nlm.nih.gov/pubmed/36678673
http://dx.doi.org/10.3390/pharmaceutics15010044

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