A Mechanistic Pharmacodynamic Modeling Framework for the Assessment and Optimization of Proteolysis Targeting Chimeras (PROTACs)

The field of targeted protein degradation is growing exponentially. Yet, there is an unmet need for pharmacokinetic/pharmacodynamic models that provide mechanistic insights, while also being practically useful in a drug discovery setting. Therefore, we have developed a comprehensive modeling framewo...

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Detalles Bibliográficos
Autores principales: Haid, Robin Thomas Ulrich, Reichel, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865105/
https://www.ncbi.nlm.nih.gov/pubmed/36678824
http://dx.doi.org/10.3390/pharmaceutics15010195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865105/
https://www.ncbi.nlm.nih.gov/pubmed/36678824
http://dx.doi.org/10.3390/pharmaceutics15010195

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